Published June 2010 | Version v1
Report Metadata-only

Significance of poly (ADP-ribosylation) enzymes and their inhibitors on heavy ion therapy

Creators

  • 1. National Cancer Center Research Inst., Biochemistry Div., Tokyo (Japan)
  • 2. National Inst. of Radiological Sciences, Chiba, Chiba (Japan)

Description

Poly(ADP-ribose) polymerase-1 (Parp-1) deficient embryonic stem (ES) cells and Poly(ADP-ribose) glycohydrolase (Parg) deficient ES cells both show increased sensitivity to gamma-irradiation. We investigated the impact of Parp-1 and Parg functional inhibition on responses to heavy ion irradiation. Parp-1 knockout mouse embryonic fibroblast (MEF) exhibited increased levels of gamma-H2AX foci, a DNA double strand break marker, compared to wild-type MEF. Parg knockout ES cells showed enhanced apoptosis after carbon-ion irradiation. These results suggest that Parp-1 and Parg could be the factors which determine the sensitivity to heavy ion irradiation. (author)

Part of:
2009 annual report of the research project with heavy ions at NIRS-HIMAC

Additional details

Identifiers

URL
http://id.nii.ac.jp/1657/00073735/;

Publishing Information

Imprint Title
2009 annual report of the research project with heavy ions at NIRS-HIMAC
Imprint Pagination
338 p.
Journal Page Range
p. 102-103
Report number
NIRS-M--234

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
53066965
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Non-conventional Literature
Descriptors DEI
ABSORBED RADIATION DOSES; APOPTOSIS; CARBON IONS; COLONY FORMATION; EMBRYONIC CELLS; FIBROBLASTS; GAMMA RADIATION; GENETIC RADIATION EFFECTS; HEAVY IONS; IRON IONS; LET; MICE; RADIOSENSITIVITY; STEM CELLS; STRAND BREAKS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CHARGED PARTICLES; CONNECTIVE TISSUE CELLS; DNA DAMAGES; DOSES; ELECTROMAGNETIC RADIATION; ENERGY TRANSFER; GENETIC EFFECTS; IONIZING RADIATIONS; IONS; MAMMALS; RADIATION DOSES; RADIATION EFFECTS; RADIATIONS; RODENTS; SENSITIVITY; SOMATIC CELLS; VERTEBRATES

Optional Information

Notes
This record replaces 45037372
Secondary number(s)
HIMAC--134