The Calculation of Ho Production by indirect Method and Preparation of Polymeric Microsphere for Radioembolisation

The reactor-produced radiolanthanides have been essential for development of therapeutic radiopharmaceuticals because they emit proper beta energies to induce tumor necrosis. Some radiolanthanides are very useful in that they have the ability of simultaneous diagnosis and therapeutic effect. This nuclide with both capacities is called as theranostic nuclide. In general, radiolanthanides can be produced by (n,γ) and (n,γ)β reaction. Of the two reactions, (n,γ)β reaction-product, shows high specific activity which is important things to affect labeling yield, is suitable for preparing the radiophamaceuticals comprising the antibody or peptide. Some radiolanthanides show the good theranostic effect in that they have proper LET (Linear Energy Transfer) to induce apoptosis for cancer and gamma ray to use as a tracer for cancer diagnosis. Although Ho-166 has been studied for therapeutic purpose since early 1990, production has been limited to direct method. To inject Dy/Ho mixture into the microsphere, we first set-up the concepts which are prior metal-administration method and posterior administration method. The latter is shown in this paper. Metal inletting process was done by using alternating between vacuum and pressurization. To prevent the leak of metal ions from metal/microsphere hybrid, surface coating was done by using interfacial reaction between saline and THF contained Poly lactic acid. Surface coating is simply completed just swiveling the vial. All experiments in this study, we just only tested with cold state