Tumor risk and nephrotoxicity in case of uranium exposure

The thesis was focused on the health hazards of chronic uranium exposure with respect to tumor evolution and nephritic lesions. Mortality rates and incidence rates were determined for different tumor types by meta-analysis of existing studies including uranium mine workers, soldiers exposed to uranium ammunition and exposure due to uranium containing drinking water. The results did not show a significant increase of mortality or incidence rates. Possible errors or deficiencies of the evaluated studies are discussed. Increased beta-2-microglobulin values might indicate the possibility of nephritic lesions.