The study of left ventricular diastolic pattern using gated cardiac blood-pool imaging and its clinical significance in the patients with coronary artery disease

Gated cardiac blood-pool imaging in 20 normal controls and 31 patients with CAD (including 17 patients with angina pectoris and 14 patients with myocardiac infarction MI) before and after sublingual NTG were presented to investigate the LV function especially the LV diastolic pattern. Abnormal peak filling rate (PFR) at rest was found in 88.2% patients with angina pectoris, though most of them (86.7%) had normal LV ejection fraction (LVEF) at rest. Abnormal LVEF and PFR at rest were found in all of the patients with MI. Patients with angina pectoris had their LVEF and PFR increased obviously after sublingual NTG. Patients with MI had only their LVEF increased slightly while PFR unchanged after sublingual NTG. Compaired with the group of controls, many patients with CAD showed abnormal PFR at rest while their LVEF were normal. Therefore, PFR is more sensitive than LVEF for the detection of CAD. We concluded the test of NTG can be applied to differentiate angina pectorris and MI, and also can be used differentiate reversible versus irreversible abnormal ventricular segmental contraction