Published February 2011 | Version v1
Journal article Metadata-only

Automation of labelling of Lipiodol with high-activity generator-produced 188Re

Creators

  • 1. Universite Europeenne de Bretagne, Rennes (France)
  • 2. INSERM U-991, Foie, Metabolismes et Cancer, 35033 Rennes (France)
  • 3. Service de Medecine Nucleaire, Centre Regional de Lutte Contre le Cancer Eugene Marquis, CS 44229, 35042 Rennes (France)
  • 4. Ecole Nationale Superieure de Chimie de Rennes, UMR CNRS 6226, Chimie Organique et Supramoleculaire, Avenue du General Leclerc, CS 50837, 35708 Rennes Cedex 7 (France)
  • 5. Service d'Oncologie Digestive, Centre Regional de Lutte Contre le Cancer Eugene Marquis, CS 44229, 35042 Rennes (France)

Description

This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol (188Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2010.11.001

Additional details

Identifiers

DOI
10.1016/j.apradiso.2010.11.001;
PII
S0969-8043(10)00429-X;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
69
Journal Issue
2
Journal Page Range
p. 426-430
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
42077060
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
AUTOMATION; EXTRACTION; LABELLING; LIPIODOL; OPTIMIZATION; RADIATION DOSES; RADIOCHEMISTRY; RHENIUM 188; SYNTHESIS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMISTRY; CONTRAST MEDIA; DOSES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; OILS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; OTHER ORGANIC COMPOUNDS; RADIOISOTOPES; RHENIUM ISOTOPES; SEPARATION PROCESSES

Optional Information

Copyright
Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.