The influence of BANXIAXIEXIN decoction and its analogous preparations on neurotensin (NT) in rat models with reflux esophagitis
Creators
- 1. Beijing Univ. of Traditional Chinese Medicine, Beijing (China)
Description
Objective: To investigate the mechanism of BANXIAXIEXIN TANG Decoction and its analogous preparations in treatment of reflux esophagitis. Methods: 60 rat models with duodenogastroesophageal reflux were divided into 4 equal numbered groups; control group, BANXIAXIEXIN TANG group, SHENGJIANGXIEXIN TANG group, GANCAOXIEXIN TANG group. The contents of NT in hypothalamus, ileum and plasma were measured by radioimmunoassay in all these models and the relationship between NT concentration and degree of esophageal mucosa injury in the control group was analysed. Results: BANXIAXIEXIN Decoction and its analogous preparations could reduce the degree of the esophageal mucosa injury significantly (p<0.01). Compared with the control group: the hypothalamus content of NT in SHENGJIANGXIEXIN TANG group was significantly lowered (p<0.05), the ileum content of NT in BANXIAXIEXIN TANG group was significantly lowered (p<0.01), the plasma contents of NT in both groups were significantly lowered (p<0.05) as well. There was positive correlation (r=0.442, p<0.01) between content of NT in ileum and degree of the esophageal mucosa injury in control group. Conclusion: NT may play an important role in the development reflux esophagitis. Regulating the synthesis and secretion of NT may be one of the mechanisms of BANXIAXIEXIN Decoction and its analogus preparations in treatment of reflux esophagitis
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 16
- Journal Issue
- 4
- Journal Page Range
- p. 215-217
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35044669
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL MODELS; CLINICAL TRIALS; CORRELATION FUNCTIONS; DATA COVARIANCES; ENKEPHALINS; ESOPHAGUS; EVALUATION; INFLAMMATION; INJURIES; LABORATORY ANIMALS; MEDICINAL PLANTS; MUCOUS MEMBRANES; NEUROREGULATORS; PATHOGENESIS; RADIOIMMUNOASSAY; RATS; STATISTICS; THERAPY
- Descriptors DEC
- ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BIOASSAY; BODY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DRUGS; ENDORPHINS; FUNCTIONS; IMMUNOASSAY; ISOTOPE APPLICATIONS; MAMMALS; MATHEMATICS; MEDICINE; MEMBRANES; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PEPTIDES; PLANTS; POLYPEPTIDES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RODENTS; SYMPTOMS; TESTING; TRACER TECHNIQUES; VERTEBRATES