Effect of varying doses of γ-rays on the content of isoenzymes of alkaline phosphatase in the blood serum and small intestine mucosa in rats

The effect of γ-irradiation with doses ranging from 350 to 15000 rad on the content of the alkaline phosphatase isoenzymes, identified in the blood serum and small intestine mucosa of rats by means of electrophoresis in the agar gel, has been investigated. The most profound lesions have been detected by the 3d day after the exposure to 1000 rad. At the doses above 1000 rad, the decrease in the activity of isoenzymes is less pronounced with the increasing content of isoforms that are detected in the small intestine mucosa of the newborn rats. These facts may be explained by the mechanisms of pathogenic effects of different gamma-ray doses