Published February 2022
| Version v1
Journal article
Parotid Gland Stem Cell Sparing Radiation Therapy for Patients With Head and Neck Cancer: A Double-Blind Randomized Controlled Trial
Creators
- 1. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)
- 2. Department of Radiation Oncology, Radiotherapiegroep, Deventer (Netherlands)
Description
Radiation therapy for head and neck cancer frequently leads to salivary gland damage and subsequent xerostomia. The radiation response of the parotid glands of rats, mice, and patients critically depends on dose to parotid gland stem cells, mainly located in the gland's main ducts (stem cell rich [SCR] region). Therefore, this double-blind randomized controlled trial aimed to test the hypothesis that parotid gland stem cell sparing radiation therapy preserves parotid gland function better than currently used whole parotid gland sparing radiation therapy.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.ijrobp.2021.09.023Additional details
Identifiers
- DOI
- 10.1016/j.ijrobp.2021.09.023;
- PII
- S0360301621028273;
Publishing Information
- Journal Title
- International Journal of Radiation Oncology, Biology and Physics
- Journal Volume
- 112
- Journal Issue
- 2
- Journal Page Range
- p. 306-316
- ISSN
- 0360-3016
- CODEN
- IOBPD3
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 53122285
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- HEAD; MICE; NECK; NEOPLASMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; RATS; SALIVARY GLANDS; STEM CELLS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BODY; DISEASES; DOSES; GLANDS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RODENTS; SOMATIC CELLS; THERAPY; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2021 Elsevier Inc.