Published December 2019 | Version v1
Journal article Metadata-only

Endocytosis mechanism in physiologically-based pharmacokinetic modeling of nanoparticles

Creators

  • 1. School of Energy Science and Engineering, Central South University, Changsha 410083, Hunan (China)
  • 2. XiangYa School of Public Health, Central South University, Changsha 410008 (China)
  • 3. School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan (China)
  • 4. School of Architecture and Art, Central South University, Changsha 410083, Hunan (China)

Description

Highlights: • Endocytosis was considered both in the blood and tissue. • The size-dependent phagocytic capacity, uptake rate, and release rate were derived. • The number concentration of AuNPs was adopted in the model. • Accumulation of AuNPs decreased with increasing size in the most organ. -- Abstract: The physiologically based pharmacokinetic (PBPK) model is a useful tool to predict the pharmacokinetics of various types of nanoparticles (NPs). The endocytosis mechanism plays a key role in pharmacokinetics of NPs. However, the effect of endocytosis mechanism both in the blood and tissue are seldom considered in PBPK model.

Additional details

Identifiers

DOI
10.1016/j.taap.2019.114765;
PII
S0041008X19303734;

Publishing Information

Journal Title
Toxicology and Applied Pharmacology
Journal Volume
384
Journal Page Range
vp.
ISSN
0041-008X
CODEN
TXAPA9

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55052413
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANIMAL TISSUES; BLOOD; CONCENTRATION RATIO; NANOPARTICLES; ORGANS; PARTICLE SIZE; PHAGOCYTES; SIMULATION; UPTAKE
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; DIMENSIONLESS NUMBERS; MATERIALS; PARTICLES; SIZE; SOMATIC CELLS

Optional Information

Copyright
Copyright (c) 2019 Elsevier Inc. All rights reserved.