Study of zinc elemental distribution in mouse brain by SRXRF
Creators
- 1. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Applied Physics
- 2. Second Military Medical Univ., Shanghai (China). Dept. of Military Hygiene
- 3. Chinese Academy of Sciences, Beijing (China). Inst. of High Energy Physics
Description
In order to explore the function and interaction between the ZnT3 mRNA expression and elemental zinc distribution in mouse brain slice, zinc concentration and its distribution were determined by SRXRF and ZnT3 mRNA expression in organs was examined by RT-PCR method. The analysis results show that the zinc content is not evenly distributed. The zinc content in cerebral cortex and hippocampus is nearly 5-10 times higher than that in other positions. Correspondingly, ZnT3 mRNA in cerebral cortex, hippocampus and testis has higher abundance, but it cna not be examined out in other organs. Furthermore, the results suggest that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play important roles in the structuring of vesicular zinc pool. (authors)
Additional details
Publishing Information
- Journal Title
- Nuclear Techniques
- Journal Volume
- 27
- Journal Issue
- 9
- Journal Page Range
- p. 655-659
- ISSN
- 0253-3219
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 37089371
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BRAIN; CONCENTRATION RATIO; MICE; POLYMERASE CHAIN REACTION; SYNCHROTRON RADIATION; TISSUE DISTRIBUTION; X-RAY FLUORESCENCE ANALYSIS; ZINC
- Descriptors DEC
- ANIMALS; BODY; BREMSSTRAHLUNG; CENTRAL NERVOUS SYSTEM; CHEMICAL ANALYSIS; DIMENSIONLESS NUMBERS; DISTRIBUTION; ELECTROMAGNETIC RADIATION; ELEMENTS; GENE AMPLIFICATION; MAMMALS; METALS; NERVOUS SYSTEM; NONDESTRUCTIVE ANALYSIS; ORGANS; RADIATIONS; RODENTS; VERTEBRATES; X-RAY EMISSION ANALYSIS
Optional Information
- Notes
- 4 figs., 1 tab., 12 refs.