Pathology in a lifespan study of x-irradiated adult female beagles

Both neoplastic and non-neoplastic disease contributed to decreased dose-related cumulative survival rates in female beagles exposed to various doses and dose rates of x radiation at one year of age. Increased dose-related cumulative incidence rates of deaths due to mammary tumors was seen in nulliparous but not in parous beagles. A markedly dose-related increase in incidence of uterine polyps was found. The importance of ovarian, thyroid, urinary bladder, and other neoplasms is discussed