Comparative toxicology of carfene in male and female rats
Creators
- 1. Radioisotopes Department, Atomic Energy Authority, Cairo (Egypt)
Description
The objective of this study was to determine the potential toxicity associated with daily oral administrations of carfene (2.5 mg/kg body weight) for 15 consecutive days on protein level in liver, kidney, brain and spleen tissues of male and female rats after 1, 5, 10 and 15 days of treatment. Evaluation of the trace elements, zinc and copper in serum, revealed that zinc level was decreased significantly while that of copper was increased in both male and female rats compared to controls. The incorporation rate of 14 C-isoleucine for synthesis of protein tended to decrease in liver tissues and increase in brain tissues of rats. Kidney and spleen tissues showed fluctuated changes. It was noticed in the present investigation that the incorporation rate of I4 C-radioactivity in different selected tissues under estimation was more pronounced in male than in female rats
Additional details
Publishing Information
- Journal Title
- Isotope and Radiation Research
- Journal Volume
- 37
- Journal Issue
- 1
- Journal Page Range
- p. 135-150
- ISSN
- 0021-1907
INIS
- Country of Publication
- Egypt
- Country of Input or Organization
- Egypt
- INIS RN
- 36114638
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- APHIDS; BLOOD SERUM; BRAIN; CARBON 14; COMPARATIVE EVALUATIONS; ELEMENTS; EXPERIMENTAL DATA; FEMALES; INSECTICIDES; KIDNEYS; MALES; ORAL ADMINISTRATION; PROTEINS; RADIOACTIVITY; RATS; SPLEEN; TOXICITY; TRACE AMOUNTS
- Descriptors DEC
- ANIMALS; ARTHROPODS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; DATA; EVALUATION; EVEN-EVEN NUCLEI; HEMIPTERA; INFORMATION; INSECTS; INTAKE; INVERTEBRATES; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; PESTICIDES; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES