Published 1990
| Version v1
Report
Synthesis of [11C]SCH 39166, a new selective D-1 dopamine receptor ligand for PET
- 1. Schering-Plough, Bloomfield, NJ (United States)
- 2. Karolinska Inst., Stockholm (Sweden)
Description
SCH 39166 ((-)-trans-6,7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo(d)naptho-(2,1-b)azepine) is a new potent D-1 dopamine antagonist which is more selective than the more commonly used SCH 23390. The authors have synthesized SCH 39166 with a carbon-11 label and conducted PET experiments in a cynomolgus monkey. Synthetic steps and in vivo experiments are discussed
Additional details
Publishing Information
- Imprint Title
- Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
- Imprint Pagination
- 458 p.
- Journal Page Range
- p. 357-358.
- Report number
- DOE/ER/60968--1
Conference
- Title
- 8. international symposium on radiopharmaceutical chemistry.
- Dates
- 24-29 Jun 1990.
- Place
- Princeton, NJ (United States).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 23029815
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference, Non-conventional Literature
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; DOPAMINE; IN VIVO; LABELLED COMPOUNDS; LABELLING; LIGANDS; METHYL IODIDE; MOLECULAR STRUCTURE; MONKEYS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS; TISSUE DISTRIBUTION
- Descriptors DEC
- AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; COMPUTERIZED TOMOGRAPHY; DISTRIBUTION; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; PHENOLS; POLYPHENOLS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS; TOMOGRAPHY; VERTEBRATES
Optional Information
- Secondary number(s)
- CONF-9006363--Absts.