Synthesis, labeling, and pharmacokinetics of 131I labeled phenylene-iodophenyl-fatty acids (PHIPA)

The application of fatty acid analogues which are trapped during β-oxidation in the mitichondria of heart muscle cells seems to be a useful approach for an improvement of myocardial scintigraphy. In order to inhibit chain degradation at distinct positions, we synthesized a new class of structurally modified 131I-labelled ω-phenylalkyl fatty acids, in which the modifying element is a p-phenylene group in the alkyl chain leading to phenylene-iodophenyl-fatty acids (PHIPA). The biodistribution of the new substances was studies in rats. (author)