Applications of isotopes in drug metabolism

The subject is reviewed under the following headings: important isotopes (C-14, tritium, S-35, Cl-36, P-32, P-33, C-12, C-13, N-14, N-15, O-16, O-17, O-18, Hydrogen, Deuterium); detection and measurement of isotopes; synthesis of labelled compounds; radioisotope studies in animals; radioisotope studies in man; use of and problems associated with labile radiolabels; non-metabolite residues; use of stable isotopes; detection and identification of metabolites; mechanistic studies; use of NMR for metabolite identification. (U.K.)