Published February 2002 | Version v1
Journal article Metadata-only

Low dose irradiation intensifying effect on cancer inhibition and its influence on skin tissue

Creators

  • 1. China Institute for Radiation Protection, Taiyuan (China)

Description

The optimized dose and mechanism of low dose irradiation intensifying effect on cancer inhibition is investigated by using mice H22 liver cancer model. The experimental result indicated that low dose irradiation has intensifying effect on cancer inhibition. The growth speed of planted tumors in the combined therapy groups significantly reduced (p < O.Ol) and the cancer cell death rate significantly increased (p < O.Ol) in comparison with in the chemical therapy. The synergism of low dose irradiation and cyclophosphamide killing cancer cells may probably be one of its mechanisms. Exposure to 60Co γ rays at low doses may influence the Zn content of skin in mice bearing tumors to certain extent. Under this experiment condition, the optimized dose is l4 cGy at which irradiation had intensifying effect on cancer inhibition but less influence on the content of Zn in the skin. (authors)

Additional details

Publishing Information

Journal Title
Radiation Protection Bulletin
Journal Volume
22
Journal Issue
1
Journal Page Range
p. 8-11
ISSN
1004-6356

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
50041934
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANIMAL TISSUES; APOPTOSIS; CARCINOMAS; COBALT 60; COMBINED THERAPY; COMPARATIVE EVALUATIONS; INHIBITION; LIVER; LOW DOSE IRRADIATION; MICE; RADIATION DOSES; SKIN; SYNERGISM
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COBALT ISOTOPES; DIGESTIVE SYSTEM; DISEASES; DOSES; EVALUATION; GLANDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RODENTS; THERAPY; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
1 fig., 3 tabs., 12 refs.