Relation between tolerance dose of skin and boron-10 concentration in neutron capture therapy for cutaneous melanoma

In boron neutron capture therapy of cutaneous melanoma, damage to scalp, facial skin and eyes must be strictly avoided. Two basic irradiation conditions follow: (1) Dose to normal skin and eyes except tumor parts must be less than the maximum tolerance dose. (2) All of the tumor must be irradiated with more than the curative dose. Since the absorbed dose depends on both neutron fluence and boron concentration, the upper and lower limits of irradiation dose are determined by the boron concentrations in normal tissue and tumor. In this report the authors describe these relationships through their clinical experiences in recently treated patients