Published July 1984
| Version v1
Journal article
5-fluorouracil metabolism monitored in vivo by 19F NMR
- 1. Saint Georges Hospital, London (UK). Medical School
- 2. National Inst. for Medical Research, London (UK)
- 3. London Hospital (UK). Medical School
- 4. Institute of Cancer Research, Sutton (UK). Surrey Branch
Description
The use of 19F NMR to monitor the in vivo metabolism of the chemotherapeutic drug, 5-fluorouracil (5FU), in tumours and in the liver of mice is described. The results clarified a number of steps in the pathway of 5FU metabolism in tumour tissue and liver which provided useful information for elucidating the antitumour mechanism of action. Thus this 19F NMR technique could be extended to clinical medicine, providing a direct, noninvasive measurement of the metabolism of the fluorinated drug both at its site of action and at its site(s) of detoxification. (U.K.)
Additional details
Publishing Information
- Journal Title
- Br. J. Cancer
- Journal Volume
- 50
- Journal Issue
- 1
- Series
- Br. J. Cancer.
- Journal Page Range
- 113-117
- ISSN
- 0007-0920
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 16013804
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- FLUORINE 19; FLUOROURACILS; IN VIVO; LIVER; METABOLISM; MICE; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE; PHARMACOLOGY
- Descriptors DEC
- ANIMALS; ANTIMETABOLITES; AZINES; BODY; DIGESTIVE SYSTEM; DISEASES; DRUGS; FLUORINE ISOTOPES; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RESONANCE; RODENTS; STABLE ISOTOPES; URACILS; VERTEBRATES