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Published May 16, 2020 | Version v1
Journal article Metadata-only

Recent updates and developments in PET imaging of prostate cancer

Creators

  • 1. Johns Hopkins University School of Medicine. The James Buchanan Brady Urological Institute and Department of Urology (United States)
  • 2. Johns Hopkins University School of Medicine. Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science (United States)
  • 3. Mayo Clinic. Division of Nuclear Medicine, Department of Radiology (United States)
  • 4. University of California San Francisco. Department of Radiology and Biomedical Imaging (United States)

Description

A number of positron emission tomography (PET) radiotracers have been developed to improve the sensitivity and specificity of imaging for prostate cancer. These radiotracers include the bone-seeking agent Na18F as well as more tumor-specific compounds such as 11C-choline and 18F-fluciclovine. In this review, we will discuss the advantages and disadvantages of these PET radiotracers for the imaging of men with prostate cancer across a range of clinical contexts. We will also touch upon radiotracers in late clinical development that have not gained regulatory approval, including those targeted against prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR).

Additional details

Identifiers

DOI
10.1007/s00261-020-02570-y;

Publishing Information

Journal Title
Abdominal Radiology (Online)
Journal Volume
45
Journal Issue
12
Journal Page Range
p. 4063-4072
ISSN
2366-0058

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55057372
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
CASTRATION; CHOLINE; FLUORINE 18; FLUORODEOXYGLUCOSE; GASTRIN; MEN; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; PROSTATE; RADIOPHARMACEUTICALS; RECEPTORS; SENSITIVITY; SKELETAL DISEASES; SPECIFICITY; TRACER TECHNIQUES; UPTAKE
Descriptors DEC
ALCOHOLS; AMMONIUM COMPOUNDS; ANIMALS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; GLANDS; HORMONES; HOURS LIVING RADIOISOTOPES; HUMANS; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; LIPOTROPIC FACTORS; MALE GENITALS; MALES; MAMMALS; MATERIALS; MEDICINE; MEMBRANE PROTEINS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PRIMATES; PROTEINS; QUATERNARY AMMONIUM COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SURGERY; TOMOGRAPHY; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020