Published June 1984 | Version v1
Journal article Metadata-only

Recent developments in the field of 123I-radiopharmaceuticals

Creators

  • 1. Essen Univ. (Gesamthochschule) (Germany, F.R.). Inst. fuer Medizinische Strahlenphysik und Strahlenbiologie

Description

Due to its advantageous nuclear physical properties iodine-123 is an excellent label for radiopharmaceuticals very well suited for measurements by γ-cameras and single-photon emission tomography. The development of 123I-radiopharmaceuticals should be based on a clear biochemical concept, reliable labelling procedures and careful pharmacokinetic studies in order to evaluate the physiological behaviour of the radioiodinated compounds being analogues of metabolic substrates. The development of 123I-labelled fatty acids and biogenic amines clearly proved the successful use of 123I for labelling compounds applied in medical diagnosis. (orig.)

Abstract (German)

Aufgrund seiner hervorragenden kernphysikalischen Eigenschaften stellt 123J ein ausgezeichnetes Radionuklid zur Markierung von Radiopharmaka dar, die somit sehr gut geeignet sind fuer Messungen mit herkoemmlichen γ-Kameras oder mittels der Single Photon Emission Tomography (SPECT). Voraussetzung fuer die Entwicklung von 123J-Radiopharmaka sind klare biochemische Konzepte, zuverlaessige Markierungsmethoden und pharmakokinetische Studien zur Ermittlung des physiologischen Verhaltens radiojodierter Verbindungen als Analoga metabolischer Substrate. Die Entwicklung 123J-markierter Fettsaeuren und biogener Amine beweist sehr deutlich die erfolgreiche Verwendungsmoeglichkeit von 123J zur Markierung von Verbindungen fuer die Anwendung in der nuklear-medizinischen Diagnose. (orig.)

Additional details

Publishing Information

Journal Title
Nuklearmedizin
Journal Volume
23
Journal Issue
3
Series
CODEN: NUKLD.;Nuklearmedizin.
Journal Page Range
111-118
ISSN
0029-5566

Conference

Title
3. international symposium on radiopharmacology.
Dates
21-25 Sep 1983.
Place
Freiburg im Breisgau (Germany, F.R.).

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
15066512
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARBOXYLIC ACIDS; DYNAMIC FUNCTION STUDIES; EMISSION COMPUTED TOMOGRAPHY; GAMMA CAMERAS; IMAGES; IODINE 123; LABELLING; METABOLISM; MICE; MYOCARDIUM; PATIENTS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SCINTISCANNING
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CAMERAS; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; TOMOGRAPHY; VERTEBRATES