Retrospective analysis of intraarterial thrombolysis in 88 patients with acute ischemic stroke

Objective: Intra arterial thrombolysis is thought to be the most effective therapy of acute ischemic stroke, a high rate of deterioration occurred after the treatment. To find the cause is the chief aim. Methods: The authors reviewed all cases of acute ischemic stroke treated by intraarterial thrombolysis, including 88 patients with collection of the basic characteristics, such as age, gender, cause, the onset, the time interval between the onset and the beginning of thrombolysis, the bleeding rate and the mortality. The authors adopted a convenient stroke scale (consciousness, movement function, nystagmus etc). For summarizing the functions of patients and then followed by reviewing the DSAs of these patients. Finally, all items above were analyzed statistically. Results: Eighty eight patients with mean age of 59(59 ± 11) years old , 63 males and 25 females were reviewed. The mean time from the onset of stroke to the beginning of thrombolysis was 5.8 hours (5.8 ± 3.3). The authors used an unique stroke scale to evaluate the neural function outcoming with 27.3% neural function worse in 24 hours after thrombolysis. The recanalization rate was 36.2% and the time delay of intraarterial thrombolysis was related to the change of neural function 24 hours after the therapy. The authors also tested the relations among age, neural function after thrombolysis, the character of the onset of the disease, results of DSA before thrombolysis and the recanalization ratio, but no positive results were found. Conclusion: Intraarterial thrombolysis is thought to have a longer treating window, therefore patients treated 6 hours after the onset of stroke would have about one third with neural function improved dramatically. (authors)