Published 2009 | Version v1
Report Open

Porous Polymer Drug-Eluting Coating Prepared by Radiation Induced Polymerization

Creators

  • 1. Research Institute for Solid State Physics and Optics, Budapest (Hungary)
  • 2. Institute of Isotopes, HAS, Budapest (Hungary)

Description

Drug-eluting stents have several advantages over bare metal implants. They eliminate restenosis, the main drawback of bare metal stents. In addition the locally delivered drug is more effective and causes less side-effects. However in some cases dangerous stent thrombosis, inflammatory and allergy reactions were observed after their implantation, which first of all related to the drug-eluting coating. This project is aimed to develop a novel biocompatible nanoporous polymer layer by radiation induced polymerization that is capable of holding and eluting drugs and promotes endothelization after the release of the drug. (author)

Files

45091341.pdf

Files (591.3 kB)

Name Size Download all
md5:c37c95e11f4637cc53cb7e67e0a17f50
591.3 kB Preview Download
Part of:
Report of the 1st RCM on ''Nanoscale radiation engineering of advanced materials for potential biomedical applications''. Working document

Additional details

Identifiers

URL
http://www-naweb.iaea.org/napc/iachem/working_materials/RC-1124-1_report_complete.pdf;

Publishing Information

Imprint Title
Report of the 1st RCM on ''Nanoscale radiation engineering of advanced materials for potential biomedical applications''. Working document
Imprint Pagination
161 p.
Journal Page Range
p. 71-79
Report number
IAEA-RC--1124.1

Conference

Title
1. RCM on nanoscale radiation engineering of advanced materials for potential biomedical applications
Dates
30 Mar - 3 Apr 2009
Place
Vienna (Austria)

INIS

Country of Publication
International Atomic Energy Agency (IAEA)
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
45091341
Subject category
S60: APPLIED LIFE SCIENCES; S36: MATERIALS SCIENCE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
DRUGS; IMPLANTS; INFLAMMATION; POLYMERIZATION; POLYMERS; POROUS MATERIALS; SIDE EFFECTS; THROMBOSIS
Descriptors DEC
CARDIOVASCULAR DISEASES; CHEMICAL REACTIONS; DISEASES; MATERIALS; PATHOLOGICAL CHANGES; SYMPTOMS; VASCULAR DISEASES

Optional Information

Notes
28 refs., 7 figs.