Published September 1, 2022 | Version v1
Journal article Metadata-only

New index to assess the extent of bone disease in patients with prostate cancer using SPECT/CT

Creators

  • 1. Toyohashi Municipal Hospital. Department of Radiology, Toyohashi, Aichi (Japan)
  • 2. Kanazawa University. Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa, Ishikawa (Japan)

Description

Objective

Assessing the extent of bone metastases in patients with prostate cancer is very important to predict patient prognosis. Therefore, the bone scan index (BSI), which is easy to use, has been used; however, the accuracy is not that high. In this study, we proposed a new index for the extent of bone disease using single-photon emission computed tomography with computed tomography (SPECT/CT) images and assessed the accuracy of calculation.

Methods

In this study, a total of 46 bone scans from 12 patients with prostate cancer treated for bone metastases with Radium-223 were included. Whole-body planar images were obtained 150-180 min after an intravenous injection of 99mTc-methylene diphosphonate, and cervical-to-pelvic SPECT/CT was immediately obtained. The total bone volume (TBV) and regional metabolic bone volume (MBV) were defined as Hounsfield unit of > 120, standardized uptake value (SUV) of > 0.5, and SUV of > 5-8 in four levels, respectively. Bone metabolism volumetric index (BMVI) was calculated as the percentage of the total MBV divided by TBV. The variability of the TBV measurement was evaluated by the percentage coefficient of variance (%CV) of TBV within individual patients. We evaluated the correlation of TBV with age, height, weight, and body mass index and the correlation and agreement between BSI and BMVI.

Results

The mean and %CV of TBV were 4661.7 cm3 and 2.8%, respectively, and TBV was strongly correlated with body weight. BMVI was significantly higher than BSI and correlated with alkaline phosphatase. For patients with progressive bone metastases, BSI was clearly underestimated, whereas BMVI was elevated.

Conclusions

Although assessed in a small number of cases, the new index for assessing the extent of bone disease using SPECT/CT imaging was highly value than BSI and was significantly correlated with alkaline phosphatase. Therefore, this study suggests that BMVI could improve the low sensitivity of BSI in patients with low extent of disease grade.

Additional details

Identifiers

DOI
10.1007/s12149-022-01783-z;

Publishing Information

Journal Title
Annals of Nuclear Medicine
Journal Volume
36
Journal Issue
11
Journal Page Range
p. 941-950
ISSN
0914-7187
CODEN
ANMEEX

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
54066382
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACCURACY; CAT SCANNING; IMAGES; METASTASES; NEOPLASMS; PATIENTS; PROSTATE; RADIUM 223; SKELETAL DISEASES; TECHNETIUM 99; VOLUME
Descriptors DEC
ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON 14 DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; EVEN-ODD NUCLEI; GLANDS; HEAVY ION DECAY RADIOISOTOPES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MALE GENITALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RADIUM ISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES

Optional Information

Copyright
Copyright (c) 2022 © The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s)
Notes
author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.