Clinical significance of determination the changes on plasma leptin and serum IL-10, IL-18 levels both before and after hemodialysis in patients with chronic renal failure

Objective: To explore the clinical significance of changes on plasma leptin and serum IL-10, IL-18 levels both before and after hemodialysis in patients with chronic renal failure. Methods: Plasma leptin and serum IL-10(with RIA), IL-18(with ELISA)levels were measured both before and after hemodialysis in 32 patients with chronic renal failure as well as in 35 normal healthy controls. Results: Before hemodialysis, plasma leptin and serum IL-10, IL-18 levels were significantly higher in the patients than those in controls(P < 0.01). After hemodialysis for 2 weeks the levels dropped markedly, but still remained significantly higher than the controls(P < 0.05). Conclusion: Measuring the changes of plasma leptin and serum IL-10, IL-18 levels in patients with chronic renal failure both before and after hemodialysis, provide definite clinical value to realize of pathosis, therapeutic efficacy and prognosis. (authors)