In vivo detection of dynamics of elements in a living rat using multitracer technique

In vivo detection technique for radioactivity of the nuclide in the multitracer intravenously administered to a living rat was proposed using a special setting of lead slit and high-purity Ge semiconducting detector. In vivo time courses of the relative distribution of 7Be, 48V, 54Mn, 58Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, and 88Y in upper abdomen and head of six week old male Wistar rats were analyzed. The dynamics of the elements were estimated using the relative distribution of 74As as base line of blood concentration, since exogenous arsenic tracer is mainly taken into red blood cell. In the head, elements distributed mainly in bones or muscles except for Co and Se, while these elements in blood. In the upper abdomen, Mn, Co, Zn, Se, Rb, V, and Y are distributed in to the liver, which is a main organ for accumulating metals. It is the first report that dynamics of biotrace elements within an hour after administration was non-invasively obtained in living animal. (author)