Published June 1, 2009 | Version v1
Journal article Metadata-only

Physical characterization of hydroxyapatite porous scaffolds for tissue engineering

Creators

  • 1. Universidade do Porto, Faculdade de Engenharia, Departamento de Engenharia Metalurgica e Materiais, Porto (Portugal)
  • 2. INEB - Instituto de Engenharia Biomedica, Divisao de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto (Portugal)
  • 3. Instituto de Ceramica y Vidrio, CSIC, 28049-Cantoblanco, Madrid (Spain)
  • 4. Faculdade de Ciencias da Saude da Universidade Fernando Pessoa, Rua Carlos da Maia, 296, 4200-150 Porto (Portugal)

Description

The present study refers to the preparation and characterization of porous hydroxyapatite scaffolds to be used as matrices for bone regeneration or as specific release vehicles. Ceramics are widely used for bone tissue engineering purposes and in this study, hydroxyapatite porous scaffolds were produced using the polymer replication method. Polyurethane sponges were used as templates and impregnated with a ceramic slurry at different ratios, and sintered at 1300 deg. C following a specific thermal cycle. The characteristics of the hydroxyapatite porous scaffolds and respective powder used as starting material, were investigated by using scanning electron microscopy, particle size distribution, X-ray diffraction, Fourier transformed infrared spectroscopy and compressive mechanical testing techniques. It was possible to produce highly porous hydroxyapatite scaffolds presenting micro and macropores and pore interconnectivity.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.msec.2008.09.052

Additional details

Identifiers

DOI
10.1016/j.msec.2008.09.052;
PII
S0928-4931(08)00278-6;

Publishing Information

Journal Title
Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems
Journal Volume
29
Journal Issue
5
Journal Page Range
p. 1510-1514
ISSN
0928-4931

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
44012228
Subject category
S36: MATERIALS SCIENCE;
Descriptors DEI
ABSORPTION SPECTROSCOPY; APATITES; BONE TISSUES; CERAMICS; INFRARED SPECTRA; MATERIALS TESTING; MATRIX MATERIALS; PARTICLE SIZE; POLYURETHANES; POROUS MATERIALS; POWDERS; REGENERATION; SCANNING ELECTRON MICROSCOPY; SKELETON; X-RAY DIFFRACTION
Descriptors DEC
ANIMAL TISSUES; BODY; COHERENT SCATTERING; CONNECTIVE TISSUE; DIFFRACTION; ELECTRON MICROSCOPY; MATERIALS; MICROSCOPY; MINERALS; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANS; PETROCHEMICALS; PETROLEUM PRODUCTS; PHOSPHATE MINERALS; PLASTICS; POLYAMIDES; POLYMERS; SCATTERING; SIZE; SPECTRA; SPECTROSCOPY; SYNTHETIC MATERIALS; TESTING

Optional Information

Copyright
Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.