Published January 1996
| Version v1
Journal article
Synthesis of [11C]methyl ketones via [11C]methylation of dithiane intermediates
- 1. Groningen Univ. Hospital (Netherlands). PET-Center
Description
A versatile synthetic route to obtain [11C] methyl ketones from aldehydes is described. Test reactions with [11C]CH3I on the model compounds 2-methyl- and 2-cyclohexyl- 1,3-dithiane followed by oxidation with N-bromosuccinimide gave almost quantitative radiochemical yields. Reaction of [11]CH3I with 2-phenylethyl-1,3-dithiane yielded the corresponding [11C]methyl ketone in 80% radiochemical yield together with an unidentified side-product on oxidation with N-bromosuccinimide. (Author)
Additional details
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 47
- Journal Issue
- 1
- Journal Page Range
- p. 57-59.
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 27025048
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; KETONES; LABELLING; METHYL IODIDE; METHYLATION; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMICAL REACTIONS; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; YIELDS