Contributions to the study of blood brain flux using radioactive tracers

In this paper, we present an original radiocirculographic method for investigates of cerebral blood flow, which has proven to be very useful, simple, and efficient for studies of brain hemodynamics. Physical considerations on injected radioactive tracer in cardiovascular system, allowed us to state a relationship for the blood flux, F, valued as the amount of fluid-blood that traverses a vascular segment in unit time. All these theoretical facts, along with a host of remarkable clinical results, are presented in a doctoral thesis entitled ^The cerebral Hemodynamics in Essential Hypertension and Arteriosclerosis of the eminent doctor Loan Muresan, who died in 1984, at only 50 years old. Using tracers marked with radioactive chrome ⁵¹Cr and iodine ¹³¹I, it was studied, for patients with various vascular diseases the blood circulation in other territories as an echo of cerebral blood flow. Outstanding results, relating to physiology, diagnosis, and therapy of some diseases, have been obtained. Through intensive collaborations, this method has been operationalized at the University Clinics of Cluj. Here, thousands of patients have been investigated, obtaining quantifiable information which highlighted the patient's condition by emergent and incident blood flows in the global circulatory process and related to other vascular segments. (author)