Effect of Ganfukang on liver function and serum hepatic fibrosis markers levels in SD rats with experimental hepatic fibrosis
- 1. The First Hospital of Dalian Medical Univ., Dalian (China)
- 2. The Second Hospital of Dalian Medical Univ., Dalian (China)
- 3. Pathophysiology Department of Dalian Medical Univ., Dalian (China)
Description
Objective: To observe the effect of Ganfukang on liver function and serum hepatic fibrosis markers levels in SD rats with experimental hepatic fibrosis. Methods: SD rat models of liver fibrosis was induced by CCl4 (n=57). Liver function (GPT, GOT) and serum hepatic fibrosis markers levels (HA, LN, C-IV, PC-III, with RIA) were tested in these models and 10 control rats. Eleven model rats were left untreated, the others were treated with Ganfukang of different concentrations and the above hepatic parameters were again determined after completion of treatment. Results: Lever function was much deteriorated and serum markers levels significantly increased in the model rats (vs controls, P<0.01). After treatment with Ganfukang, the improvement was significant (vs untreated models, P<0.01). Conclusion: Ganfukang is of definite therapeutic value for experimental hepatic fibrosis in rat models. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 17
- Journal Issue
- 4
- Journal Page Range
- p. 283-284
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36114264
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ABSORPTION SPECTROSCOPY; ALBUMINS; AMINOTRANSFERASES; BIOLOGICAL FUNCTIONS; BIOLOGICAL MARKERS; BIOLOGICAL MODELS; BLEOMYCIN; BLOOD SERUM; COLLAGEN; DIAGNOSIS; FIBROSIS; GLOBULINS; HYALURONIC ACID; LIVER; MEDICINAL PLANTS; MUCOPROTEINS; RADIOIMMUNOASSAY; RATS
- Descriptors DEC
- AMINES; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBOHYDRATES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DRUGS; ENZYMES; GLANDS; IMMUNOASSAY; ISOTOPE APPLICATIONS; MAMMALS; MATERIALS; MUCOPOLYSACCHARIDES; NITROGEN TRANSFERASES; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PLANTS; POLYSACCHARIDES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RODENTS; SACCHARIDES; SCLEROPROTEINS; SPECTROSCOPY; TRACER TECHNIQUES; TRANSFERASES; VERTEBRATES
Optional Information
- Notes
- 3 tabs., 3 refs.