Published 1986 | Version v1
Journal article Metadata-only

In vivo skeletal localization properties of sup(99m)Tc complexes of large phosphonate ligands

Creators

  • 1. Missouri Univ., Columbia (USA). Dept. of Radiology
  • 2. Dow Chemical Co., Freeport, TX (USA)
  • 3. Harry S. Truman Memorial Veterans Hospital, Columbia, MO (USA)

Description

Tetramethylenephosphonate derivatives of norborane (TPNB) and dicyclopentadiene (TPDCPD) were shown to readily form stable chelates with sup(99m)Tc that had high and selective bone uptake. The skeletal uptake and blood clearance properties of sup(99m)Tc-TPNB were similar to sup(99m)Tc-MDP in both rats and rabbits. This suggests additional studies to further evaluate sup(99m)Tc-TPNB or perhaps other large-organic based multidentate phosphonate ligands as potential bone imaging agents is warranted. (author)

Additional details

Publishing Information

Journal Title
Nucl. Med. Biol.
Journal Volume
13
Journal Issue
1
Series
Nucl. Med. Biol.
Journal Page Range
31-37
ISSN
0883-2897
CODEN
NMBIE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18028054
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BONE TISSUES; CHELATES; DIAGNOSIS; IMAGES; IN VIVO; LIGANDS; NUCLEAR MEDICINE; PHOSPHONIC ACID ESTERS; SKELETON; TECHNETIUM 99; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPLEXES; CONNECTIVE TISSUE; ESTERS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TISSUES; YEARS LIVING RADIOISOTOPES