Published July 6, 1993 | Version v1
Patent Metadata-only

Radiolabeled anti platelet monoclonal antibody for imaging in-vivo thrombi

Creators

Description

A radiolabeled monoclonal antibody radiolabeled with a halogen or metallic radionuclide selected from the group consisting of 123I, 125I, 131I, 111In-DTPA, 99mTc and 97Ru, wherein the monoclonal antibody is of the class IgG, produced by a hybridoma formed by fusion of cells from a BALB/C mouse myeloma line, X63.Ag8.653 and spleen cells from a BALB/c mouse previously immunized with human blood platelets, which antibody: (a) reacts readily with normal human platelets and with dog platelets; (b) fails to react with thrombasthenic human platelets or human platelets whose GPIIb/IIIa complex is dissociated with EDTA and (c) reacts slowly with inactivated platelets and substantially twice as rapidly with ADP activated platelets; and (d) completely blocks the interaction of fibrinogen with platelets induced by ADP

Availability note (English)

Available from Patent and Trademark Office, Box 9, Washington, DC 20232 (United States).

Additional details

Publishing Information

Imprint Pagination
[10 p.].
IPC:
Int. Cl. A61K 49/02; A61K 39/395.
IPC
Int. Cl. A61K 49/02; A61K 39/395.
Patent number
US patent document 5,225,181/A/

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
25009886
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Non-conventional Literature
Descriptors DEI
ADP; BLOOD PLATELETS; CHEMICAL PREPARATION; DIAGNOSIS; DIAGNOSTIC USES; DOGS; DTPA; EDTA; INDIUM 111; IODINE 123; IODINE 125; IODINE 131; ISOMERIC NUCLEI; LABELLING; MAN; MICE; MONOCLONAL ANTIBODIES; RADIOPHARMACEUTICALS; RUTHENIUM 97; SPLEEN CELLS; TECHNETIUM 99; THROMBOSIS; TUMOR CELLS
Descriptors DEC
AMINO ACIDS; ANIMAL CELLS; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CARDIOVASCULAR DISEASES; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; RUTHENIUM ISOTOPES; SOMATIC CELLS; SYNTHESIS; TECHNETIUM ISOTOPES; USES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Secondary number(s)
US patent application 7-826,650.