Published March 19, 2008 | Version v1
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Oncogene mRNA Imaging with Radionuclide-PNA-Peptides

Creators

Description

New cancer gene hybridization probes to carry radionuclides were made. Noninvasive technetium-99m gamma imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated, followed by noninvasive technetium-99m imaging of MYC cancer gene activity. Noninvasive imaging of CCND1 cancer gene activity in human breast cancer tumors in mice was demonstrated with a positron-emitting copper-64 probe, followed by noninvasive positron imaging of IRS1 cancer gene activity.

Availability note (English)

Also available from OSTI as DE00925560; PURL: https://www.osti.gov/servlets/purl/925560-GWqr7o/

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Additional details

Identifiers

URL
https://www.osti.gov/servlets/purl/925560-GWqr7o/;
DOI
10.2172/925560;

Publishing Information

Imprint Pagination
2 p.
Report number
DOE/ER--63055

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
41078689
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
COPPER 64; GENES; MAMMARY GLANDS; MICE; NEOPLASMS; ONCOGENES; RADIOISOTOPES; RNA
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COPPER ISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GENES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; VERTEBRATES

Optional Information

Contract/Grant/Project number
FG02-00ER63055
Notes
doi 10.2172/925560
Funding organization
USDOE - Office of Science Biological and Environmental Research/Medical Sciences (United States)