Published February 1995
| Version v1
Journal article
On-line anion exchange purification of [13N]NH3 produced by 10 MeV proton irradiation of dilute aqueous ethanol
- 1. Laboratory of Radiopharmaceutical Chemistry (Belgium). Faculty of Pharmaceutical Science
- 2. Nuclear Medicine, U.Z. Gasthuisberg, Leuven (Belgium)
Description
[13N]NH3 prepared by irradiating dilute aqueous ethanol with 10 MeV protons is contaminated with small amounts of [18F]fluoride and [13N]NO2-/NO3-. The content of 18F is negligible at end of bombardment but increases as a function of time due to the longer half-life of 18F. We developed a simple on-line purification method in which the irradiated water directly passes through a small anion exchange column. Both the radionuclide impurity [18F]fluoride and the radiochemical impurities [13N]NO3-/NO2- are efficiently removed by this procedure which results in highly pure (> 99.9%) [13N]NH3 preparations. (author)
Additional details
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 46
- Journal Issue
- 2
- Journal Page Range
- p. 83-86.
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 26039932
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AMMONIA; CHEMICAL PREPARATION; IMPURITIES; ION EXCHANGE; LABELLING; NITROGEN 13; ON-LINE SYSTEMS; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HYDRIDES; HYDROGEN COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS