Published January 1977 | Version v1
Journal article Metadata-only

Parametric method for estimation of dose-modifying factors: low-dose extrapolation limit

Creators

  • 1. Univ. of Texas, Houston

Description

A parametric method for the estimation of dose-modifying factors (DMF) is developed, using the linear-quadratic model of radiation effect. The method presented generalizes DMFs to include ratios, such as relative biological effectiveness (RBE), which may vary with dose. A statistical test for constant DMF is derived and a limit to reliable low-dose extrapolation of estimates of the DMF is presented. The relationship of the method presented here to the usual ''straight-line'' method, and a recently developed nonparametric method is discussed. Using cell survival data for 16-MeV neutrons and 60Co, the RBE of 16-MeV neutrons is computed by all three methods for comparison

Additional details

Additional titles

Augmented title (English)
16 MeV neutrons, "6"0Co

Identifiers

DOI
10.2307/3574512;

Publishing Information

Journal Title
Radiation Research
Journal Volume
69
Journal Issue
1
Series
Radiat. Res.
Journal Page Range
1
ISSN
0033-7587

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
8315213
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; COBALT 60; DOSE-RESPONSE RELATIONSHIPS; DOSIMETRY; GAMMA RADIATION; LOW DOSE IRRADIATION; NEUTRONS; RBE; STATISTICS; SURVIVAL TIME
Descriptors DEC
BARYONS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FERMIONS; HADRONS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATHEMATICS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEONS; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
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