A case of malignant pheochromocytoma treated with 131I-metaiodobenzylguanidine and alpha-methyl-p-tyrosine
Creators
- 1. Tokyo Women's Medical Coll. (Japan)
Description
A 47-year-old man had surgery for paraaortic paraganglioma in 1980 and 1985. In 1987, his urinary excretion of catecholamines and metabolites was extremely high. Scintigraphy with 131I-metaiodobenzylguanidine (MIBG) showed multiple bone and liver metastases. He was teated twice with infusions of 3.7 GBq of 131I-MIBG. After the first treatment, he had transient hypertension and pain in the back and right leg. Subsequent 131I-MIBG scintigraphy showed that the number of metastatic tumors had decreased. The second treatment was less effective. Excessive catecholamines were treated with alpha-methyl-p-tyrosine (MPT), a catecholamine synthesis inhibitor, at doses between 250 and 2000 mg/day, which significantly decreased urinary NE excretion. This is the first case treated with 131I-MIBG in Japan. (author)
Additional details
Publishing Information
- Journal Title
- Japanese Journal of Medicine
- Journal Volume
- 29
- Journal Issue
- 3
- Series
- Jpn. J. Med.
- Journal Page Range
- 329-333
- ISSN
- 0021-5120
- CODEN
- JJMDA
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 22016371
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CATECHOLAMINES; GUANIDINES; IODINE 131; NEOPLASMS; ORAL ADMINISTRATION; PATIENTS; RADIONUCLIDE ADMINISTRATION; RADIOTHERAPY; SCINTISCANNING; THYROID; UPTAKE
- Descriptors DEC
- AMINES; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ENDOCRINE GLANDS; GLANDS; HYDROXY COMPOUNDS; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIOISOTOPE SCANNING; RADIOISOTOPES; THERAPY