Erdheim-Chester disease

Three cases of Erdheim-Chester disease are presented, and the clinical and radiographic features of the disease are described. Although clinical manifestations related to skeletal involvement are often absent or mild, those due to histiocytic infiltration in other organ systems, including the heart, pericardium, lungs, and retroperitoneal tissues, can be prominent. Radiographic changes in the skeleton are characteristic, consisting most typically of diffuse sclerosis of the diaphyses and metaphyses of the long tubular bones