Published February 1998 | Version v1
Journal article Metadata-only

Study of technetium chemistry. Pt.10: Qsar analysis of 99Tcm-labelled N2S2 analogues of brain imaging agents

Creators

  • 1. Beijing Normal Univ. (China). Dept. of Chemistry

Description

Quantitative structure activity relationship (QSAR) analysis of the correlations between initial brain uptake and structure parameters, for example lipophilicity Fr, molar refractivity MR and electronic parameters σ1 of the 99Tcm-N2S2 complexes have been studied with multiple regression analysis method. The main structural factors which affect the initial brain uptake of this kind of brain imaging agents have been discussed. The results may give some theoretical information for designing new brain imaging agents

Additional details

Publishing Information

Journal Title
Journal of Nuclear and Radiochemistry
Journal Volume
20
Journal Issue
1
Journal Page Range
p. 14-19
ISSN
0253-9950

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
29043702
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; CONTRAST MEDIA; LABELLING; MOLECULAR STRUCTURE; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIOPHARMACEUTICALS; REGRESSION ANALYSIS; TECHNETIUM 99; TECHNETIUM COMPLEXES; UPTAKE
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPLEXES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MATHEMATICS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; STATISTICS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; YEARS LIVING RADIOISOTOPES