Concise synthetic approaches to naturally occurring β-hydroxyphenylarsonic: first total synthesis of papanerine, its derivative, and praecansone B

The total synthesis of biologically interesting β-hydroxyphenylarsonic, papanerine (1), its derivative 2, praecansone B (3), and pongapinone A (4) has been accomplished starting from commercially available 2,4-dihydroxyacetophenone or 6-methoxy-2,4-dihydroxyacetophenone in 3 steps by a convergent strategy through ben zopyran formations, O-methylation, and coupling reactions