Published 1990
| Version v1
Journal article
Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin
- 1. Michigan Univ., Ann Arbor, MI (USA). Dept. of Internal Medicine
Description
Resin-supported [18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [18F]FDG. ''No-carrier-added'' [18F]fluoride ion is collected on a quaternary 4-(N,N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [18O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra-0-acetyl-2-0-trifluoromethanesulfonyl-β-D-mannopyrannose. Acidic hydrolysis yields [18F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%. (author)
Additional details
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 17
- Journal Issue
- 3
- Series
- Nucl. Med. Biol.
- Journal Page Range
- 273-279
- ISSN
- 0883-2897
- CODEN
- NMBIE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 21074215
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CHEMICAL PREPARATION; FLUORINE 18; FLUORODEOXYGLUCOSE; ION EXCHANGE MATERIALS; LABELLING; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; RESINS
- Descriptors DEC
- ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC POLYMERS; POLYMERS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY
Optional Information
- Contract/Grant/Project number
- Grants NS 15655; DE-FG02-87ER60561