Changes in the hemopoietic system and in hemoregulatory cytokines caused by acute γ-irradiation or combined radiation-thermal injuries

Acute radiation and combined radiation-thermal injuries (CRTIs) were modelled in the experiments on CBA x C57B16 mice. Changes in the concentration of endogenic and lipopolysaccharide-induced TNF-α in the blood serum were measured in 3 to 24 h after γ-irradiation at a dose of 7 Gy and a combined radiation-thermal injury. The status of mature and reserve pools of the bone marrow granulocytes was determined from the reaction of leukocytes mobilization to blood in response to the administration of interleukin-1β in 48 h after irradiation and CRTI. The contents of IL-3 and IL6 in the blood serum, the level of cytokine secretion by the bone marrow cells were determined in vitro in the peak phases of acute radiation and combined injuries. 18 refs., 2 figs., 4 tabs