Published November 1999 | Version v1
Journal article Metadata-only

Hepatic ASGP receptor image of 99mTc-NGA in normal rabbit

Creators

  • 1. Jiangsu Inst. of Nuclear Medicine, Wuxi (China). National Laboratory of Nuclear Medicine

Description

Galactosyl-neo-glyco-albumin (NGA) is a specific ligand of asialo-glycoprotein receptor (ASGPR) in hepatocyte surface. The imaging comparison of 99mTc-NGA and 99mTc-HSA in normal rabbit imaging are reported. 99mTc-HSA generated a blood pool image when injected into normal rabbit, while 99mTc-NGA showed a hepatic receptor image characteristics. If rabbit hepatic receptor had been saturated with 100 times amounts of NGA, 99mTc-NGA would generate a blood pool imaging similar to 99mTc-HSA. Flow cytometry (FCM) analysis with FITC-NGA also showed that ASGPR could be obviously saturated. Therefore, 99mTc-NGA is a hepatic receptor image agent

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
22
Journal Issue
11
Journal Page Range
p. 663-667
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
31009853
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BLOOD FLOW; BLOOD SERUM; CONTRAST MEDIA; GALACTOSE; LABELLING; LIVER; LIVER CELLS; PROTEINS; RABBITS; RADIOISOTOPE SCANNING; RADIOPHARMACEUTICALS; RECEPTORS; TECHNETIUM 99
Descriptors DEC
ALDEHYDES; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBOHYDRATES; COUNTING TECHNIQUES; DIGESTIVE SYSTEM; DRUGS; GLANDS; HEXOSES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MONOSACCHARIDES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; SOMATIC CELLS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES