Published February 1987 | Version v1
Journal article Metadata-only

Rejoining of double strand breaks in normal human and ataxia-telangiectasia fibroblasts after exposure to 60Co γ-rays, 241Am α-particles or bleomycin

Creators

  • 1. Kernforschungszentrum Karlsruhe G.m.b.H. (Germany, F.R.). Inst. fuer Genetik und Toxikologie von Spaltstoffen
  • 2. Kernforschungszentrum Karlsruhe G.m.b.H. (Germany, F.R.). Hauptabteilung Sicherheit

Description

The rejoining of DNA double strand breaks (dsb) induced by 60Co γ-rays, 241Am α-particles or bleomycin was measured by neutral filter elution. In agreement with their colony-forming ability, ataxia-telangiectasia cells (AT2BE) and normal fibroblasts exhibited similar dsb rejoining capacity following α-irradiation, but showed marked differences in the rejoining kinetics of dsb induced by γ-rays or bleomycin. (author)

Additional details

Publishing Information

Journal Title
Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
Journal Volume
51
Journal Issue
2
Series
Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
Journal Page Range
209-218
ISSN
0020-7616
CODEN
IJRBA

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18064633
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ALPHA PARTICLES; AMERICIUM 241; BLEOMYCIN; DNA REPAIR; FIBROBLASTS; GAMMA RADIATION; HEREDITARY DISEASES; STRAND BREAKS; TELANGIECTASIS
Descriptors DEC
ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; ANIMAL CELLS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CARDIOVASCULAR DISEASES; CHARGED PARTICLES; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; HEAVY NUCLEI; HELIUM IONS; IONIZING RADIATIONS; IONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIATIONS; RADIOISOTOPES; SOMATIC CELLS; SPONTANEOUS FISSION RADIOISOTO; YEARS LIVING RADIOISOTOPES