The preparation and biodistribution of a new 99Tcm-nitrito complex 99TcmN-MIBI
Creators
- 1. Beijing Normal Univ. (China). Dept. of Chemistry
Description
The technetium-99m nitrito intermediate is synthesized by using SnCl2·2H2O as reductant, and the complex 99TcmN-MIBI is obtained through ligand exchange reaction. The labelling yield of 99TcmN-MIBI is over 95% by TLC. The conditions of preparing 99TcmN-MIBI are optimized. Results of stability and partition coefficient of 99TcmN-MIBI indicate that the complex is lipophilic and stable over 10 h at room temperature. The biodistribution of 99TcmN-MIBI in mice shows high myocardium uptake, and rather rapid clearance. For 5-min post-injection the heart-to-blood, heart-to-lung and heart-to-liver ratios are 3.18, 1.72 and 1.42, respectively. The new complex may be suitable for instant myocardial imaging. 99TcmN-MIBI has significant different biodistribution characteristics from 99Tcm-MIBI. Based on these promising properties, 99TcmN-MIBI should be a new potential myocardial perfusion imaging agent
Additional details
Publishing Information
- Journal Title
- Journal of Isotopes
- Journal Volume
- 10
- Journal Issue
- 3
- Journal Page Range
- p. 158-162.
- ISSN
- 1000-7512
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 29001116
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHEMICAL PREPARATION; CONTRAST MEDIA; DISTRIBUTION FUNCTIONS; ISONITRILES; LABELLING; MICE; MYOCARDIUM; RADIOPHARMACEUTICALS; STABILITY; TECHNETIUM COMPLEXES; TECHNETIUM 99; TIN CHLORIDES; TISSUE DISTRIBUTION; UPTAKE
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; CARDIOVASCULAR SYSTEM; CHLORIDES; CHLORINE COMPOUNDS; COMPLEXES; DISTRIBUTION; DRUGS; HALIDES; HALOGEN COMPOUNDS; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYNTHESIS; TECHNETIUM ISOTOPES; TIN COMPOUNDS; TIN HALIDES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES