Possible prediction of synergistic effects at a whole organism level

The possibility of applying the synergistic model developed for description of combined agents effect on the cell system to the impact at the whole organism level by two tests - the survival and carcinogenesis - in the laboratory animals and human beings is demonstrated. The published data on synergistic effects were used in this work. It is shown that the character of the agents interaction depends on the ratio of induced injuries not only on the cell but also on the whole organism level; the existence of the maximum synergism and the condition whereby it obtained is theoretically substantiated. It is forecasted that the maximum value of the synergism coefficient should be observed by the agents combined impact only by their definite ratio (N2/N1) and that any deviation of this ratio from the optimal one should lead to its decrease