Published May 1988
| Version v1
Journal article
Metabolic effects of 3'-deoxyadenosine (cordycepin) and 2-halo-3'-deoxyadenosine on repair of X-ray-induced potentially lethal damage in Chinese hamster V79 cells
- 1. Hokkaido Univ., Sapporo (Japan)
Description
Using cultured Chinese hamster V79 cells, an attempt has been made to examine the phosphorylation of cordycepin and its 2-halo derivatives (2-chloro-3'-deoxyadenosine, 2-bromo-3'-deoxyadenosine, and 2-iodo-3'-deoxyadenosine) by adenosine kinase, within the cells, and to correlate it with their cytotoxicities and abilities to inhibit the repair of X-ray-induced potentially lethal damage (PLDR). Of all compounds, only cordycepin was found to be phosphorylated and showed both potent cytotoxicity and ability to inhibit PLDR
Additional details
Publishing Information
- Journal Title
- Radiat. Res.
- Journal Volume
- 114
- Journal Issue
- 2
- Series
- Radiat. Res.
- Journal Page Range
- 231-239
- ISSN
- 0033-7587
- CODEN
- RAREA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19104599
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ADENOSINE; ANIMAL CELLS; CELL CULTURES; DNA; DNA REPAIR; GENETIC RADIATION EFFECTS; HAMSTERS; LUNGS; PHOSPHORYLATION; PHOSPHOTRANSFERASES; RADIOSENSITIVITY; X RADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; CHEMICAL REACTIONS; ELECTROMAGNETIC RADIATION; ENZYMES; GENETIC EFFECTS; IONIZING RADIATIONS; MAMMALS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANS; PHOSPHORUS-GROUP TRANSFERASES; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RIBOSIDES; RODENTS; TRANSFERASES; VERTEBRATES