Published January 1980
| Version v1
Journal article
Effects of misonidazole during continuous low dose rate irradiation
Creators
Description
To determine the effects of misonidazole during continuous low dose rate irradiation EMT6/SF tumor was exposed to continuous irradiation at 4.2 and 1.64 rads/minute with and without misondiazole in bilaterally nephrectomized mice, and the results were compared to those obtained with acute exposures. Radiosensitization by misonidazole at a clinically achievable plasma concentration was observed during continuous low dose rate irradiation. The DMF (dose-modifying factor) varied with drug dose and dose rate. Cytotoxicity was also observed with drug exposure greater than 6 hours. Our results suggest that it would be advantageous to use misonidazole during low dose rate brachytherapy
Additional details
Additional titles
- Augmented title (English)
- Mice
Publishing Information
- Journal Title
- Cancer Clin. Trials
- Journal Volume
- 3
- Journal Issue
- 3
- Series
- Cancer Clin. Trials.
- Journal Page Range
- 257-265
- ISSN
- 0190-1206
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 13664537
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACUTE IRRADIATION; CHRONIC IRRADIATION; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL NEOPLASMS; LOW DOSE IRRADIATION; MICE; MISONIDAZOLE; NEPHRECTOMY; RADIOSENSITIVITY; RADIOTHERAPY
- Descriptors DEC
- ALCOHOLS; ANIMALS; ANTINEOPLASTIC DRUGS; AZOLES; DISEASES; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; IRRADIATION; MAMMALS; MEDICINE; NEOPLASMS; NITRO COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; RODENTS; SURGERY; THERAPY; VERTEBRATES