Electron-donor and -acceptor functions of physiologically active substances. XI. Influence of an alkyl substituent in phosphorylated oximes on their complex formation with chloroform-d

Phosphorylated alkanoyl chloride oximes were prepared from trialkyl phosphites and the corresponding 1,1-dichloro-1-nitrosoalkenes. In the formation of complexes of chloroform-d with the oximes synthesized the intensity of the stretching vibrations of the carbon-deuterium bond rises considerably, and this provides a basis for the correct evaluation of the stability constants of the complexes. In the series of compounds studied a substantial change was observed in the stability of the complexes with chloroform-d with variation of the chain length and degree of branching of the alkyl group Alk, and this change goes in parallel with the change in the inhibiting activity of the given oximes with respect to certain enzymes