Clinical significance of determination of changes of blood P-selectin and TNF levels after operation in patients with rectal cancer
Description
Objective: To study the clinical significance of changes of blood P-selectin and TNF levels after operation in patients with rectal cancer. Methods: Serum TNF (with RIA) and plasma P-selectin (with ELISA) levels were determined in 34 patients with rectal cancer both before and after operation as well as in 35 controls. Results: Before operation, blood P-selectin and TNF levels were significantly higher in the patients than those in controls (P<0.01). Twenty-two of the 30 patients underwent operation showed no sign of recurrence at 1 year and their blood P-selectin and TNF levels dropped to within normal range. However in the 8 patients with recurrence, blood levels of P-selectin and TNF remained abnormally high (vs those without recurrence, P < 0. 01). Conclusion: Blood P-selectin and TNF levels were closely related to the disease process of rectal cancer and were of prognostic values. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 18
- Journal Issue
- 4
- Journal Page Range
- p. 282-283
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 39091435
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD PLASMA; BLOOD SERUM; ENZYME IMMUNOASSAY; GLYCOPROTEINS; NEOPLASMS; RADIOIMMUNOASSAY; RECTUM; RESPONSE MODIFYING FACTORS; SURGERY
- Descriptors DEC
- BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBOHYDRATES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; GASTROINTESTINAL TRACT; IMMUNOASSAY; INTESTINES; ISOTOPE APPLICATIONS; LARGE INTESTINE; MATERIALS; MEDICINE; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; SACCHARIDES; TRACER TECHNIQUES
Optional Information
- Notes
- 2 tabs., 6 refs.