Automated synthesis of 5-[18F]fluoro-2'-deoxyuridine

An automated synthesis system for the production of 5-[18F]fluoro-2'-deoxyuridine ([18F]FdUrd) has been developed for routine clinical use. The reaction process consists of addition of 18F2 to 3,5-di-O-acetyl-2'-deoxyuridine, hydrolysis of 18F-adduct and purification of [18F]FdUrd on tandem columns of ion retardation resin and alumina. These procedures are controlled by a microcomputer. The system provides about 30 mCi of [18F]FdUrd in a sterile and pyrogen-free aqueous solution with a radiochemical yield of 20% and a radiochemical purity of over 98% within 60 min after the 60-min irradiation with a current of 12 μA. (author)