Published August 1998 | Version v1
Journal article Metadata-only

Diagnoses of gastric cancer and other gastric diseases by serum pepsinogen I and II levels

Creators

  • 1. Jiangsu Inst. of Nuclear Medicine, Wuxi (China). State Key Laboratory of Nuclear Medicine
  • 2. Hospital of Zhejiang Medical College, Zhenjiang (China)

Description

Serum pepsinogens I and II (PGI, PGII) levels were determined by PGI and PGII-RIA kits in 84 healthy controls and 128 patients of gastric diseases including 42 patients with gastric cancer. The results showed peptic ulcer cases had elevated PGI and PGII levels. The atrophic gastritis cases had low PGI levels and the gastric cancer cases had low PGI and low PGI/PGII ratio. Using the cut-off values of PGI<35 μg/L and PGI/PGII<1.5 for clinical purpose, the sensitivity and specificity of the test for gastric cancer was 73% and 78%, respectively. Combined with endoscope examination, the serum PGI and PGII levels are valuable for the early diagnosis of gastric cancer

Additional details

Publishing Information

Journal Title
Nuclear Science and Techniques
Journal Volume
9
Journal Issue
3
Journal Page Range
p. 148-149
ISSN
1001-8042

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
29052874
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; COMPARATIVE EVALUATIONS; DIAGNOSTIC TECHNIQUES; GASTRECTOMY; IMMUNE SERUMS; PEPSIN; RADIOIMMUNOASSAY; STOMACH
Descriptors DEC
ACID PROTEINASES; BODY; DIGESTIVE SYSTEM; DISEASES; ENZYMES; EVALUATION; GASTROINTESTINAL TRACT; HYDROLASES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MEDICINE; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HYDROLASES; PROTEINS; RADIOASSAY; SURGERY; TRACER TECHNIQUES